These actors and actresses guest starred for multiple episodes on One Tree Hill. Sorted by most episodes! The list is long!!

♥ Vaughn Wilson as Fergie Thompson
♥ Cullen Moss as Junk Moretti
♥ Daphne Zuniga as Victoria Davis
♥ Bevin Prince as Bevin Mirskey
♥ Kate Voegele as Mia Catalano
♥ Brett Claywell as Tim Smith
♥ Michael May as Chuck Scolnik
♥ Bryan Greenberg as Jake Jagielski
♥ Allison Munn as Lauren
♥ Ashley Rickards as Samantha Walker
♥ Kieren Hutchinson as Andy Hargrove
♥ Kelsey Chow as Gigi Silveri
♥ Shawn Shepard as Principal Turner
♥ Bradley Evans as Jerry
♥ Michaela McManus as Lindsey Strauss
♥ Robbie Jones as Quentin Fields
♥ Katherine Landry as Madison
♥ Torrey DeVitto as Nanny Carrie
♥ Joe Manganiello as Owen Morello
♥ Amanda Schull as Katie Ryan/Sara Evans
♥ India de Beaufort as Miranda Stone
♥ Daniella Alonso as Anna Tagarro
♥ Michael Copon as Felix Tagarro
♥ Gregory Harrison as Paul Norris
♥ Maria Menounos as Jules
♥ Mitch Ryan as Alexander Coin
♥ Mike Grubbs as Grubbs
♥ Emmanuelle Vaugier as Nicki
♥ Sheryl Lee as Elizabeth ‘Ellie’ Harp
♥ Jaden Harmon as Andre Fields
♥ Lindsey McKeon as Taylor James
♥ Burgess Jenkins as Bobby Irons
♥ Matt Barr as Derek/Ian Banks
♥ Kate French as Renee Richardson
♥ Scott Holroyd as David Lee Fletcher
♥ Laura Izibor as Erin Macree
♥ Paul Teal as Josh Avery
♥ Kelley Davis as Mrs. Scolnik
♥ William Haze as Rick
♥ Devin McGee as Xavier
♥ Sarah Edwards as Theresa
♥ Pierce Gagnon as Logan
♥ Sharon Lawrence as Sylvia Baker
♥ Kevin Kilner as Larry Sawyer
♥ Peter Riegert as Dr. August Kellerman
♥ Michael Trucco as Cooper Lee
♥ Elisabeth Harnois as Shelley Simon
♥ Richard Burgi as Ted Davis
♥ David Norona as Dr. Alvarez
♥ Ernest Waddell as Derek Sommers
♥ Evan Peters as Jack Daniels
♥ Katherine Bailess as Eric Marsh
♥ Stephen Elliot as Officer Stephens
♥ Eric McIntire as Ian Kellerman
♥ Chelsea Kane as Tara Richards
♥ Kelly Lintz as Alice
♥ Sasha Jackson as Kylie
♥ Patrick Stogner as Young Keith
♥ Amber Wallace as Glenda Farrell
♥ B.J. Britt as Devon Fox
♥ Bess Armstrong as Lydia James
♥ Thomas Ian Griffith as Larry Sawyer
♥ Rick Fox as Daunte
♥ Andrew Elvis Miller as Dimitri
♥ Conrad Goode as Bear
♥ Keedar Whittle as Nino
♥ James Van der Beek as Reese Dixon
♥ Renee Vincent as Mrs. Edwards
♥ Andrea Moore as Makenna
♥ Colin Fickes as Jimmy Edwards
♥ Amy Parrish as Shari Smith
♥ Dax Griffin as Wade Scolnik
♥ Kevin Federline as Jason
♥ Chris Beetem as Dr. Ethan Copeland
♥ Leven Rambin as Chloe Hall
♥ Allison Scagliotti as Abby Brown
♥ Rey Valentin as Nick Chavez
♥ Dawnn Lewis as Denise Fields
♥ John Doe as Mick Wolf
♥ Mary Kate Englehardt as Lily Roe Scott
♥ Susan Walters as Principal Rimkus
♥ Steven Howell as Troy Jameson
♥ Lance Tafelski as Sergei
♥ Texas Battle as Tony Battle
♥ Marcus Coloma as Marcus
♥ Mark Schwahn as Max
♥ Mark Joy as Mayor Mullins
♥ Cassandra Jean as Missy
♥ Nick Lachey as Himself
♥ Dikran Tulaine as John Knight
♥ Hailey Wist as Molly
♥ Zachary Dylan Smith as Young Dan
♥ Gavin DeGraw as Himself
♥ Blake Bashoff as Gary
♥ Huey Lewis as Jim James
♥ Fall Out Boy as Themselves
♥ Michelle Branch as Herself
♥ Michelle Featherstone as Herself
♥ Dave Nagarro as Himself
♥ Nick Zano as Himself
♥ Peyton List as Solaris
♥ Jerry Rice as Himself